CBD and pain: your natural painkiller
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The Enecta products are not medicines. They are obtained from hemp varieties registered in the Common European Register, in compliance with the requirements set by Law 242/2016. This product is registered as a cosmetic for external use and not intended for oral use or therapeutic purposes.
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Why do we talk about CBD oil as a pain reliever?
The cannabidiol or CBD is a natural anti-inflammatory that acts on the receptors of the endocannabinoid system, a system responsible for maintaining the body's homeostasis. CBD works to rebalance this system when a stimulus, such as pain, causes an imbalance. In particular, it interacts with CB2 receptors, which are mainly found in immune system cells and in some areas of the central nervous system, promoting the modulation of the inflammatory response.
Furthermore, the CBD modulates the GABAergic system, the brain's primary inhibitory system, helping to reduce the perception of pain. It can also interact with TRPV1 receptors, known as vanilloid receptors, which are involved in pain perception and body temperature regulation. The activation of these receptors by the CBD can promote the desensitization of pain pathways, naturally reducing the painful sensation.
CBD drops for pain: what does science say?
The CBD, which is a non-toxic and non-psychoactive compound, has been the subject of numerous studies that have shown its usefulness in management of different forms of pain, predominantly refractory to opioid treatment.
CBD and inflammatory pain
CBD has been found useful to support the body in case of inflammatory pain. In fact, in many inflammatory conditions, such as arthritis, CBD acts as a natural anti-inflammatory and prevents its worsening. In a study conducted by theInsubria University of Varese has been highlighted that cannabis oil can help inhibit the production of cytokines, which are inflammatory molecules. Cannabidiol also acts on certain chemical processes of anandamide, an endocannabinoid linked to pain perception. CBD is often used when inflammation is at the root of the problem. For example, it has been found effective for the vulvodynia and for the cervical pain.
CBD and chronic pain
Most studies on CBD and chronic pain have indicated a pain reduction ranging from 43 to 66%, a rather promising result especially for such a troublesome and complex condition. One study published on Journal of Pain on cannabis and chronic pain has focused on demonstrating the safety of CBD, which is in every respect a safe and natural molecule.
In an interesting survey conducted in 2021 on 878 people suffering from fibromyalgia, a syndrome characterized by widespread chronic pain, CBD proved to be an effective natural alternative for 72% of the participants, who used it instead of traditional medications for chronic pain, such as NSAIDs, opioids, and benzodiazepines. Those who took part in the survey reported better pain and sleep management and a reduction or complete discontinuation of medications.
CBD and neuropathic pain
Some studies they have demonstrated the effectiveness of cannabidiol on neuropathic pain. In particular, it has proven promising against the peripheral neuropathic pain caused by chemotherapeutics and in the regulation of adenosine receptors, involved in the transmission and chronicization of pain.
The effects of CBD are not limited to chronic neuropathic and inflammatory pain, but have also been observed in many other clinical conditions, such as multiple sclerosis, epilepsy, insomnia, schizophrenia, and many other diseases resistant to drug therapy. According to a scientific review on CBD and pain, cannabidiol is an effective pain reliever capable of improving not only the painful condition but also sleep and quality of life overall.
The peculiarity of CBD, in fact, is that its action is not limited to modulating the inflammatory response. This cannabinoid can interact with serotonin receptors, a neurotransmitter involved in regulating mood and anxiety. This interaction allows CBD to exert an anxiolytic and relaxing effect, which can be particularly valuable for those suffering from chronic pain.
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CBD After Sport:
- promotes muscle recovery
- helps to relieve joint and muscle pain after physical activity
- helps reduce bruising
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CBD for joint pain: a study on arthritis
According to one study on the effectiveness of cannabidiol for joint pain, CBD oil or hemp oil with CBD can help reduce joint pain by up to 44%.
The study used an anonymous questionnaire to assess the effectiveness of cannabidiol on different types of arthritis: osteoarthritis, rheumatoid arthritis, and autoimmune arthritis The test was conducted on a sample of 428 volunteers.
83% of people who used CBD reported an overall improvement in pain, 66% also associated cannabidiol with an improvement in physical function and sleep quality. Compared to different types of arthritis, the greatest benefit was reported by participants with osteoarthritis issues. The same study highlighted how the use of CBD helps reduce the use of anti-inflammatory drugs. 259 participants reported a decrease or even cessation of the use of medications such as anti-inflammatories, paracetamol, and opioids.
Another search on CBD and arthritis rheumatoid highlights an anti-arthritic activity by cannabidiol, which could improve arthritis by targeting synovial fibroblasts under inflammatory conditions.
Is hemp oil an anti-inflammatory?
Hemp oil is known for its anti-inflammatory properties. This is largely due to its composition rich in essential fatty acids, including alpha-linolenic acid (omega-3) and linoleic acid (omega-6), which play a crucial role in reducing systemic inflammation.
Unlike many food sources that contain excess omega-6, hemp oil has a balanced ratio of omega-3 to omega-6, usually 1:3. This balance is essential for maintaining a healthy inflammatory response. Additionally, omega-3 and omega-6 are precursors to prostaglandins, hormone-like substances that modulate the inflammatory process. Omega-3s in particular stimulate the production of anti-inflammatory prostaglandins, while omega-6s contribute to cell regeneration without triggering inflammation.
In addition to omega-3 and omega-6, hemp oil also contains a range of natural antioxidants, including vitamin E. Antioxidants help combat oxidative stress, which is one of the main causes of chronic inflammation in the body.
Although it has anti-inflammatory properties, hemp oil is not a painkiller, but it is an excellent carrier oil that effectively supports the anti-inflammatory and pain-relieving action of cannabidiol.
CBD and pain therapy
Abbiamo intervistato il dottor Calvanese, esperto di terapia del dolore, sull’applicazione della Cannabis Sativa L. e del CBD in ambito oncologico. Durante l'interview, Calvanese told us that there are numerous studies on the subject. In particular, studies conducted by doctors Massimo Nabissi and Marco Falasca within a project that started at Shanghai University and continued in Italy.
These are studies that illustrate therapeutic innovations for certain types of cancer, which also include the administration of cannabis sativa and CBD. Researchers have discovered that both pancreatic carcinoma and glioblastoma multiforme, two very aggressive forms of tumors, express a protein called CBR55.
The cannabidiol has the ability to act directly on this protein, blocking it and triggering programmed cell death. Calvanese argues that for an oncology patient, undergoing a therapeutic plan based on cannabis can be advantageous and bring several benefits. In particular, CBD helps to significantly reduce pain and stimulate appetite, which often disappears after chemotherapy cycles and moral decline.
CBD and Therapeutic Cannabis
Given its beneficial properties, cannabidiol is also present in therapeutic cannabis preparations, that is, cannabis for medicinal use, which can only be taken with a medical prescription for specific conditions. When referring to therapeutic cannabis, we mean “Cannabis FM-2,” which contains a THC percentage between 5% and 8% and a CBD percentage between 7.5% and 12%, and is produced in Italy in compliance with European regulations on medicines. The production process is strictly controlled and takes place at an authorized pharmaceutical facility, managed by the Military Institute of Florence and under the supervision of the AIFA (Italian Medicines Agency). The distribution of therapeutic cannabis is regulated by the State Cannabis Agency, which operates within the Ministry of Health. Furthermore, for several years, some Italian pharmacies have been producing galenic preparations with THC concentrations that can reach up to 19%.
What is pain?
The pain is a sensation experienced due to specific nerve fibers that carry pain impulses from the periphery to the brain, which in turn integrates and modifies the pain information. This system is known as the ascending pain pathway. There is also a descending pain pathway, which sends signals from the brain to the periphery carrying the message to turn off the pain. Various neurotransmitters such as glutamate or GABA are involved in these mechanisms.
The pain can be of different types:
- Sharp: the acute pain is sudden and has a short duration related to its cause, such as a surgical intervention, trauma, or localized inflammation.
- Chronic: Chronic pain is characterized by the presence of persistent pain lasting more than six months, often even in the absence of an obvious cause. Unlike acute pain, which is a natural response of the body to an injury or inflammation and tends to disappear when the problem is resolved, chronic pain persists even after the triggering cause has disappeared. The painful sensation is often accompanied by other symptoms, such as chronic fatigue, muscle stiffness, and sleep disturbances, resulting in a significant impact on quality of life.
- Neuropathic: a type of chronic pain that is particularly difficult to treat. Neuropathic pain is caused by nerve damage and can manifest as tingling, burning, or stabbing pain.
How to relieve pain naturally
Therapeutic massage
Massages can improve blood circulation, reduce muscle tension, and stimulate the release of endorphins, natural chemicals that act as painkillers.
Relaxation techniques
Relaxation techniques such as meditation, deep breathing, and yoga can help reduce stress and improve pain management.
Heat or ice application
Hot or cold compresses can provide relief depending on the type of pain. Heat can help relax muscles, while cold can reduce inflammation and numb the area.
Anti-inflammatory diet
A diet rich in anti-inflammatory foods, such as fruits, vegetables, omega-3 rich fish, and spices like turmeric and ginger, can help reduce inflammation and pain.
Acupressure and acupuncture
These traditional practices can help stimulate specific points on the body, promoting energy flow and reducing the perception of pain.
Natural supplements
Some supplements such as fish oil, bromelain, and glucosamine can be helpful for relieving joint and muscle pain.
Essential oils
Essential oils such as lavender, peppermint, and rosemary can be used for massages or aromatherapy, helping to reduce pain and discomfort.
Physiotherapy
Physical therapy can be an effective way to treat pain, with professionals using targeted exercises and manual therapies to improve physical function.
Regular physical exercise
Constant practice of physical activity can improve flexibility and reduce muscle stiffness, contributing to relief from chronic pain.
Adequate water intake
Keeping the body well hydrated is essential for overall health and can positively affect pain management.
What to eat to reduce inflammation?
Here is a table with a series of useful foods to include in your diet to reduce inflammation.
If you find it useful you can download it here
Read one of the articles from our blog
CBD, vulvodynia and endometriosis
A study on cannabis and vulvodynia symptoms suggests that CBD may significantly reduce pain and improve the quality of life in women with vulvodynia and be generally helpful for pelvic pain and other typically female conditions such as endometriosis.
CBD pain reliever: cost
The cost of CBD to be used as a painkiller, therefore in a percentage of about 10% to 24%, ranges from 30 to 80 euros for a 10 ml format and from 79 to 179 for the 30 ml format.
CBD oil and migraine, testimonials and clinical studies
In this article, we have gathered some scientific evidence and some of our customers' reviews on migraine and headache. For some people, migraine is an extremely complex disorder, and it is interesting to know that CBD can be a very effective natural aid...
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Do you still have doubts?
Here are the answers to the most frequently asked questions from our customers
A review of over 130 published studies in the literature reports that even at high doses of CBD/CBG (up to 1500mg/day) there are no significant side effects.
In particular, no alteration of the main physiological parameters has been demonstrated.
In humans, the minimal side effects observed in some studies they have mainly been diarrhea, fatigue, and changes in appetite.
No, using CBD or CBG has the great advantage of not causing addiction and therefore dependence.
To date, no problems of abuse or physical dependence related to the intake of CBD or CBG have been demonstrated in the literature, either in animals or humans.
No, CBD, unlike THC, does not have psychoactive effects; on the contrary, numerous studies highlight how it can help counteract or reduce the negative effects of THC. The search suggests that rather than defining the Cannabidiol non-psychoactive substance should be defined as non-intoxicating, because it appears to lack the characteristics that could turn it into a substance capable of causing abuse or dependence phenomena.